Evaluation of 4-methylcyclohexanemethanol (MCHM) in a combined irritancy and Local Lymph Node Assay (LLNA) in mice
نویسندگان
چکیده
منابع مشابه
Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA).
Genomic technologies have the potential to enhance and complement existing toxicology endpoints; however, assessment of these approaches requires a systematic evaluation including a robust experimental design with genomic endpoints anchored to traditional toxicology endpoints. The present study was conducted to assess the sensitivity of genomic responses when compared with the traditional local...
متن کاملComparison of Responses in the Murine Local Lymph Node Assay (LLNA) Between CBA and BALB/c Mouse Strains
While CBA is currently the recommended strain for the LLNA, the assay was originally developed using BALB/c mice. Since the introduction of the LLNA, several groups in the U.S. have published LLNA studies using BALB/c mice, including the National Toxicology Program, the National Institute for Occupational Safety and Health, and the Dow Chemical Corporation. This has resulted in reference databa...
متن کاملValidation studies on an alternative endpoint for the local lymph node assay (LLNA-DA): Importance of study management
We conducted 2 validation studies for a modified version of the local lymph node assay (LLNA), which was designated as the LLNA-DA. A total of 17 laboratories tested the validity of the assay by using 14 chemicals. Here, in addition to the experimental protocol, we prepared the study protocols describing the study purpose, the role of the participants, etc. Technology transfer was conducted by ...
متن کاملA comparative evaluation of in vitro skin sensitisation tests: the human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA).
We previously developed the human cell-line activation test (h-CLAT) in vitro skin sensitisation test, based on our reported finding that a 24-hour exposure of THP-1 cells (a human monocytic leukaemia cell line) to sensitisers is sufficient to induce the augmented expression of CD86 and CD54. The aim of this study is to confirm the predictive value of h-CLAT for skin sensitisation activity by e...
متن کاملevaluation of sadr eminence in safavid period
چکیده: یکی از دوره های مهم تاریخی ایران به لحاظ تأمین استقلال ملی مذهبی و حتی تأثیر آن بر فرهنگ و مذهب ایرانیان، دوره صفویه است. رسمیت دادن و رواج مذهب شیعه توسط شاه اسماعیل اول، یکی از مهمترین اقدامات این دولت محسوب می شود. بنابراین برای اجرای این سیاست، وی منصب صدارت را به عنوان منصبی مذهبی- حکو متی ایجاد کرد .این منصب از دوره ی تیموریان ایجاد شده بود ولی در اواخر این دوره اهمیت بیشتری یافت...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Food and Chemical Toxicology
سال: 2017
ISSN: 0278-6915
DOI: 10.1016/j.fct.2017.03.034